Most just lately, it has been recognized that conolidine and the above derivatives act on the atypical chemokine receptor three (ACKR3. Expressed in related areas as classical opioid receptors, it binds to the big selection of endogenous opioids. Not like most opioid receptors, this receptor functions being a scavenger and will not activate a next

Conolidine’s analgesic results stem from its conversation with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors while in the central nervous program, conolidine modulates alternate molecular targets. A Science Improvements study uncovered that conolidine interacts Together with the atypical chemokine receptor ACKR3/CXCR